Protein Details: ATP-sensitive inward rectifier potassium channel 15

Protein ID

ICDB_Pro_1421

Protein Name

ATP-sensitive inward rectifier potassium channel 15

Gene Name

KCNJ15

Organism

Homo sapiens (Human)

Length

375 amino acids

AlphaFoldDB

AF-Q99712-F1-model_v4.pdb

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium

Sequence

MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQRERELRTLLLQQSNV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Joubert Syndrome and Renal Hypomagnesemia With Ocular Involvement

Location

DOI ID

10.1006/geno.1997.4865; 10.1074/jbc.272.1.586; 10.1038/35012518; 10.1101/gr.2596504; 10.1006/mcne.1998.0679; 10.1126/science.1133427

RefSeq

NP_001263364.1; NP_001263365.1; NP_001263366.1; NP_001263367.1; NP_001263368.1; NP_002234.2; NP_733932.1; NP_733933.1; XP_005261032.1; XP_006724065.1; XP_011527862.1; XP_011527863.1; XP_016883832.1; XP_016883833.1; XP_016883834.1